Two Isoforms of Npap60 (Nup50) Differentially Regulate Nuclear Protein Import
نویسندگان
چکیده
منابع مشابه
Two Isoforms of Npap60 (Nup50) Differentially Regulate Nuclear Protein Import
Npap60 (Nup50) is a nucleoporin that binds directly to importin alpha. In humans, there are two Npap60 isoforms: the long (Npap60L) and short (Npap60S) forms. In this study, we provide both in vitro and in vivo evidence that Npap60L and Npap60S function differently in nuclear protein import. In vitro binding assays revealed that Npap60S stabilizes the binding of importin alpha to classical NLS-...
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ژورنال
عنوان ژورنال: Molecular Biology of the Cell
سال: 2010
ISSN: 1059-1524,1939-4586
DOI: 10.1091/mbc.e09-05-0374